Modern treatment methods help to prolong and improve the lives of comorbid patients

Every year, combined pathologies become an increasingly pressing medical problem, complicating treatment and worsening the condition of patients. At the V All-Russian Forum, general practitioners discussed how to prevent and combat complications of common diseases.

Every third patient over 50 years of age has 2–3 concomitant diseases[1]. This complicates the course of each disease and affects approaches to therapy. For example, comorbidity slows down the recovery process after COVID-19 infection.

“Helping patients recover from COVID is critically important, as the disease often makes itself known over a long period of time, significantly reducing the quality of life. “The emergence of effective and, importantly, safe therapy for different groups of patients is a step towards returning to normal life,”
emphasized Galina Lvovna Ignatova, Dr. habil. med., professor, chief pulmonologist of the Ural Federal District, in her speech.

One of the treatment options for patients with pulmonary symptoms after COVID-19 is Longidaza®. Long-Cov-III-21 study[2] demonstrated that the drug increased the proportion of patients with a 10% increase in forced vital capacity, and also helped reduce the occurrence of common post-Covid symptoms such as fatigue and malaise after exercise.

Another respiratory pathology that is aggravated by comorbidity is pneumococcal infection. Past pneumonia, often caused by pneumococcus, affects the health of older people, increasing the likelihood of developing cardiovascular disease, dementia and other cognitive disorders, and increasing the likelihood of death within a year[3][4].

Despite a large number of scientific studies[5], confirming a reduction in overall mortality due to immunization of the population against pneumococcal infection, vaccination coverage of the adult population in the country remains low.

“Rosstat data show that only 8.6% of adults in Russia are vaccinated against pneumococcus,”
emphasized Oksana Mikhailovna Drapkina, academician of the Russian Academy of Sciences and chief physician of the Russian Ministry of Health.

Another pathology, which in 60% of cases is combined with or provokes the development of other pathologies, is osteoarthritis[6][7].

“Osteoarthritis is not just a joint disease, but a condition that affects various body systems, and therefore requires a comprehensive and personalized approach to therapy,”
emphasizes Lyudmila Ivanovna Alekseeva, Dr. habil. med., Professor of the Department of Rheumatology at the I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russia.

Physical therapy, diet and modern complex treatments help reduce the level of inflammation in osteoarthritis. A number of clinical studies have demonstrated a significant symptomatic effect of native collagen in osteoarthritis . Results of recent studies of the Artneo®complex, which includes undenatured type II collagen, showed a reduction in pain, stiffness and an improvement in functional state of joints and quality of life of patients with osteoarthritis after just 2 months of use.


1Gubanova G.V., Belyaeva Yu.N., Shemetova G.N. COMORBID PATIENT: STAGES OF FORMATION, RISK FACTORS AND TACTICS OF MANAGEMENT // Modern Problems of Science and Education. – 2015. – No. 6.

2Clinical Trials. Efficacy and Safety of Longidaza® for the Treatment of Patients With Residual Changes in the Lungs After COVID-19.

3 Ramirez JA, Wiemken TL, Peyrani P, Arnold FW, Kelley R, Mattingly WA, Nakamatsu R, Pena S, Guinn BE, Furmanek SP, Persaud AK, Raghuram A, Fernandez F, Beavin L, Bosson R, Fernandez-Botran R, Cavallazzi R, Bordon J, Valdivieso C, Schulte J, Carrico RM; University of Louisville Pneumonia Study Group. Adults Hospitalized With Pneumonia in the United States: Incidence, Epidemiology, and Mortality. Clin Infect Dis. 2017 Nov 13;65(11):1806-1812. doi: 10.1093/cid/cix647. PMID: 29020164.

4 Shea KM, Edelsberg J, Weycker D, Farkouh RA, Strutton DR, Pelton SI. Rates of pneumococcal disease in adults with chronic medical conditions. Open Forum Infect Dis. 2014 May 27;1(1):ofu024. doi: 10.1093/ofid/ofu024. PMID: 25734097; PMCID: PMC4324183.

5 The protective effect of pneumococcal vaccination on cardiovascular disease in adults: A systematic review and meta-analysis F. Marra, A. Zhang, E. Gillman, K. Bessai, K. Parhar, N.K.Vadlamudi International Journal of Infectious Diseases V. 99 Pages 204-213 (October 2020) DOI: 10.1016/j.ijid.2020.07.038

6 Swain S, Sarmanova A, Coupland C, Doherty M, Zhang W. Comorbidities in Osteoarthritis: A Systematic Review and Meta-Analysis of Observational Studies. Arthritis Care Res (Hoboken). 2020 Jul;72(7):991-1000. doi: 10.1002/acr.24008. Epub 2020 Jun 7. PMID: 31207113.

7 Dell'Isola A, Pihl K, Turkiewicz A, Hughes V, Zhang W, Bierma-Zeinstra S, Prieto-Alhambra D, Englund M. Risk of Comorbidities Following Physician-Diagnosed Knee or Hip Osteoarthritis: A Register-Based Cohort Study. Arthritis Care Res (Hoboken). 2022 Oct;74(10):1689-1695. doi: 10.1002/acr.24717. Epub 2022 Jun 22. PMID: 34086422.

8 Rezuş E, Burlui A, Cardoneanu A, Macovei LA, Tamba BI, Rezuş C. From Pathogenesis to Therapy in Knee Osteoarthritis: Bench-to-Bedside. Int J Mol Sci. 2021 Mar
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