Meet the updated Uronext®: now available for children from 7 years old

Cystitis, both acute and chronic, is a common problem affecting a large number of women of different ages. Statistics says that every second woman in Russia has had an episode of acute cystitis at least once in her life, and every sixth has had a chronic manifestation of the disease, as revealed by Konstantin Tevlin, urologist, PhD in Medicine, at the 24th Mother and Child All-Russian Scientific and Educational Forum.

He also noted that lower urinary tract infection is the third most common infection, second only to gastrointestinal tract infections and acute respiratory diseases. According to Konstantin Tevlin, in 80-90% of cases, acute cystitis is caused by E. coli, followed by bacterial colonization and biofilm formation, which antibiotics alone cannot destroy.

Cranberry-based complexes disrupt the formation of biofilms and have an anti-microbial and anti-inflammatory effect. Clinical studies reveal that the risk of urinary tract infection is 26% lower when using a standardized cranberry extract[1].

“Uronext® contains the unique branded cranberry extract Cran-Max with proanthocyanidins in the most beneficial and sufficient amount,”
added Konstantin Tevlin.

Chronic cystitis is very difficult to treat as it seems today, so doctors are focusing on preventive measures that can minimize relapses. For example, dietary supplements such as cranberry or D-mannose may stop recurring cystitis by preventing bacteria from attaching to the urinary tract epithelium[2].

Uronext® contains 2000 mg of D-mannose, providing a fourfold reduction in exacerbations of cystitis[3],[4]. The new composition of Uronext® presented on the market today includes vitamin D in an increased amount of 500 IU, which will allow patients to boost local immunity and the body’s defenses when fighting against acute cystitis.

In addition, since October, Uronext® has been approved for children starting from 7 years of age.

“The synergistic effect Uronext® provides, with its three components: cranberry extract, D-mannose and vitamin D, affects the pathogenetic developmental mechanisms of acute cystitis, has a powerful immunomodulatory effect and restores the bladder mucosa damaged by inflammation,”
concluded his speech Konstantin Petrovich Tevlin.

1 Fu Z, Liska D, Talan D, et al: Cranberry reduces the risk of urinary tract infection recurrence in otherwise healthy women: a systematic review and meta-analysis. J Nutr 147(12):2282-2288, 2017. doi: 10.3945/jn.117.254961

2 Armelle J. Cystites récidivantes: des moyens de prévention non médicamenteux [Recurrent cystisis: No medicine preventive means]. Prog Urol. 2017;27(14):823-830. doi:10.1016/j.purol.2017.09.006

3 Jean-Marc Bohbot. Results of a randomized, double-blind study on the prevention of recurrent cystitis with GynDelta®. The Gynaecologist’s and Obstetrician’s Journal. January 2007 (a special issue from the C.C.D laboratory).

4 Kranjčec B., Papeš D., Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World Journal of Urology. 2014; 32 (1): 79–84.
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