Experts discuss modern infertility treatment methods

At the XVII International Congress on Reproductive Medicine which took place in Moscow, experts discussed major causes of infertility and highlighted modern methods of its treatment.

A number of gynecological disorders of the pelvic organs as well as various surgical interventions may directly influence the development of infertility. Among other causes, Mikhail Murashko, Minister of Health of the Russian Federation, mentioned the novel coronavirus infection as one of the causes. He emphasized the importance of timely vaccination of both pregnant women and for those who are just planning to become parents.

One of the main threats to women’s reproductive health is often adhesive processes. For example, diseases such as uterine fibroid and endometriosis often require surgical intervention, which leads to the development of adhesions, in severe cases, contributing to infertility. For example, adhesions often form after myomectomy, the uterine fibroid removal, the most common benign tumor in women. According to Professor Natalya Schukina, M.D., Ph.D., intrauterine adhesions form on average in 45–50% of cases after surgery.

To minimize adverse outcomes and reduce the risk of adhesions, endocrinotherapy is used, but in the first two months after surgery, there is a risk of developing thrombosis. So, according to experts, more safe and more effective methods are the use of enzyme products that prevent the growth of pathological connective tissue.

These include Russian drug Longidaza (bovhyaluronidaze azoximer), which helps to reduce the density of existing adhesions and lowers the risk of forming new ones. The molecule has anti-inflammatory and anti-fibrotic activity and can be used to increase bioavailability when administered with antibiotics.

“Longidaza has a pronounced anti-adhesion effect, offering a six-fold reduction in the incidence of uterine synechiae after surgery. The use of this drug can improve the results not only after myomectomy but also after any gynecological surgery, including infertility and endometriosis”, Natalia Schukina summarizes.

Adhesions can occur not only after surgery but also as a consequence of gynecological disorders. Professor Maria Yarmolinskaya, M.D., Ph.D., said that endometriosis, which is a chronic disease, leads to adhesions in at least 60% of cases due to local inflammatory reactions in the body.

“Our main goal is to achieve the most effective use of medical therapy, avoid repeated surgical interventions and ensure a decent quality of life. The application of combination therapy of endometriosis with the inclusion of a bovhyaluronidaze azoximer-based drug contributes to a more intense reduction of pelvic pain, a significant improvement in quality of life and a decrease in inflammatory and adhesive processes, compared to monotherapy”, Maria Yarmolinskaya summarizes.

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